Grow

with us

with us

Life at Aliada

At Aliada, our working environment is more than just a workplace; it’s a collaborative ecosystem where every team member is an essential ally. We foster a culture of support, encouragement, and shared success, ensuring that everyone contributes to our collective mission of making a positive impact on the lives of those affected by central nervous system diseases.

We have a robust employee benefits program, including:

  • Competitive compensation package
  • Employer paid premiums for medical, dental and vision benefits from
    Blue Cross Blue Shield
  • Employer fully funded health savings accounts (HSA)
  • Employer-paid premiums for short-term, long-term disability and life/AD&D insurance
  • 401K Plan
  • Flexible paid time off
  • Paid leave benefits
  • Training and career development opportunities
  • Commuter benefits

Explore Open Positions

Senior Scientist/Principal Scientist – Alzheimer’s Disease Research-Biology

Apply Now

Aliada Therapeutics is a pioneering biotech company located in Boston, with a focused vision of advancing next-generation CNS therapeutics for patients. Aliada is driven by a seasoned team with collaborative experience and success across neurologic and biologic drug development. At the core of Aliada’s innovation lies a proprietary Modular Delivery (MODEL) platform, capable of transporting large molecule therapeutics across the blood-brain barrier (BBB). The platform, originally engineered at Janssen (Edavettal et al. 2022), includes a toolkit that enables tailoring of exposure and therapeutic functionality, including two distinct BBB-receptor targets (TfR and CD98) and a design that can accommodate a variety of therapeutic cargoes including antibodies, oligonucleotides, and enzymes. Aliada is applying the MODEL platform to multiple targets and modalities, with its most advanced program, ALIA-1758 entering a Phase 1 SAD clinical study.   We are looking to build our team with colleagues who are intellectually curious, driven, accountable, and collaborative.

Role Summary

Aliada Therapeutics is currently searching for a Senior/Principal Scientist to join our dynamic team focused on Alzheimer’s disease research. The successful candidate will play a key role in advancing our understanding of neurodegeneration and developing novel therapies for Alzheimer’s disease. This position offers an exciting opportunity to contribute to cutting-edge research in a fast-paced environment.

Responsibilities:

  • Design, plan, and execute in vitro and in vivo experiments to advance antibody molecules from hit to lead.
  • Use strong biochemistry skills to characterize protein aggregates in vitro and ex vivo.
  • Oversee imaging studies using Alzheimer’s disease models.
  • Previous experience working with antibodies as therapeutic agents is a plus.
  • Analyze experimental data, interpret results, and present findings to internal teams and external stakeholders.
  • Collaborate effectively with cross-functional teams and contract research organizations to drive research projects forward and achieve key milestones.
  • Stay abreast of the latest scientific literature and technological advancements in the field of Alzheimer’s disease research.
  • Mentor junior team members, provide scientific guidance, and contribute to a collaborative and inclusive work environment.

Skills and Requirements:

  • PhD in Biochemistry, Neuroscience, or a related field with a focus on Alzheimer’s disease research or related neurodegenerative field with 5+ years of relevant experience post PhD.
  • Proven track record of designing and executing complex experiments in the field of neurodegeneration.
  • Strong expertise in in vitro techniques such as cell culture, protein analysis, and molecular biology assays.
  • Experience with in vivo models of Alzheimer’s disease, including mouse models.
  • Experience in managing external CROs.
  • Proficiency in imaging techniques, high content imaging and confocal microscopy is a plus.
  • Excellent analytical and problem-solving skills, with the ability to critically evaluate scientific data.
  • Demonstrated ability to work effectively in a multidisciplinary team environment and collaborate with colleagues from diverse backgrounds.
  • Strong communication skills, including the ability to present complex scientific concepts clearly and concisely.
  • Adaptability to work in a fast-paced, dynamic research environment with changing priorities and deadlines.

Senior Research Associate – Biology

Apply Now

Aliada Therapeutics is a pioneering biotech company located in Boston, with a focused vision of advancing next-generation CNS therapeutics for patients. Aliada is driven by a seasoned team with collaborative experience and success across neurologic and biologic drug development. At the core of Aliada’s innovation lies a proprietary Modular Delivery (MODEL) platform, capable of transporting large molecule therapeutics across the blood-brain barrier (BBB). The platform, originally engineered at Janssen (Edavettal et al. 2022), includes a toolkit that enables tailoring of exposure and therapeutic functionality, including two distinct BBB-receptor targets (TfR and CD98) and a design that can accommodate a variety of therapeutic cargoes including antibodies, oligonucleotides, and enzymes. Aliada is applying the MODEL platform to multiple targets and modalities, with its most advanced program, ALIA-1758 entering a Phase 1 SAD clinical study. We are looking to build our team with colleagues who are intellectually curious, driven, accountable, and collaborative.

Role Summary

Aliada Therapeutics is currently searching for a Senior Research Associate with experience in cell-based assays and animal management to join the Oligonucleotide team. The successful candidate will help execute and analyze cell-based assays, assist in developing and onboarding new biochemical and cell-based assays, and assist in mouse colony management.

Responsibilities:

  • Work in a cross-functional team to advance ASO or siRNA knockdown modalities for therapeutic applications.
  • Plan and execute experiments to evaluate and optimize oligonucleotide-design in cell-based assays.
  • Participate in the design and scaling of assays for drug candidate screening in cell-based assays.
  • Analyze and interpret data from molecular pharmacology studies.
  • Assist in mouse colony management and tissue collection.
  • Maintain detailed records of experiments.
  • Attend and present data at internal team meetings.

 Skills and Requirements:

  • BS/MS in biology, biochemistry, cellular/molecular biology, or related discipline with 3+ years of post-graduate research experience in an academic or industry setting. PhD with 0+ years of post-graduate research experience will also be considered.
  • Experience in cell and molecular biology including mammalian cell culture, mRNA isolation/quantitation by qPCR, sequencing (NGS/Sanger), protein quantification by ELISA and western blot is required.
  • Experience with animal colony management, animal handling, in vivo surgeries, and in vivo protocol writing is highly desired.
  • Hands-on experience in working with samples in 96- or 384-well plate format is desired.
  • Familiarity with CNS disease models, DNA/RNA editing tools, and oligonucleotide therapeutics is a plus.
  • Outstanding aptitude for experimental design and execution, efficient assay development and creative problem solving.
  • Capacity to be highly productive in a fluid and fast-paced work environment.
  • Committed and collaborative team player

Senior Director – Protein Chemistry CMC

Apply Now

Aliada Therapeutics is a pioneering biotech company located in Boston, with a focused vision of advancing next-generation CNS therapeutics for patients. Aliada is driven by a seasoned team with collaborative experience and success across neurologic and biologic drug development. At the core of Aliada’s innovation lies a proprietary Modular Delivery (MODEL) platform, capable of transporting large molecule therapeutics across the blood-brain barrier (BBB). The platform, originally engineered at Janssen (Edavettal et al. 2022), includes a toolkit that enables tailoring of exposure and therapeutic functionality, including two distinct BBB-receptor targets (TfR and CD98) and a design that can accommodate a variety of therapeutic cargoes including antibodies, oligonucleotides, and enzymes. Aliada is applying the MODEL platform to multiple targets and modalities, with its most advanced program, ALIA-1758 entering a Phase 1 SAD clinical study. We are looking to build our team with colleagues who are intellectually curious, driven, accountable, and collaborative.

 

Role Summary

Aliada Therapeutics is currently searching for a Senior Director of Protein Chemistry CMC. This key resource will lead the strategic build of the CMC team driving innovation and developing forward-looking strategies for the development and commercialization of next-generation products.

Responsibilities:

· Lead a team of CMC scientists working with cross-functional R&D partners to develop therapeutic biologic candidates from early development through BLA approval.

· Accountable for the success and overall CMC quality of the diverse Aliada portfolio projects including multi-specific antibodies, enzyme fusions, and antibody-oligo conjugates.

· Provide strong functional technical leadership and ensure timely completion of all functional deliverables including reports and applicable quality and regulatory documents.

· Responsible for the Module 3 content of global filings, and high-quality CMC dossiers.

· Key member of teams that participate in communication and meetings with global Health Authorities along the development continuum.

· Reviews contracts with Third Party CDMOs, CROs, and consultants. Develops a budget in collaboration with R&D senior leadership and stays within the approved funding.

· Critically evaluates and integrates formulation, drug substance, drug product, analytical control strategy and device inputs to an overarching CMC strategy that

aligns with corporate business objectives and current regulatory / compliance requirements.

· Recruit and develop top talent to create and maintain a productive team of highly skilled scientists and project leaders. Establish and maintain an environment that ensures retention of key talent through continued development opportunities and recognition of key accomplishments.

· Ensures compliance with regulatory, health, safety, and environmental requirements. Is always informed of trends and breakthrough developments in the global technical, regulatory and compliance arena and industry practices.

Skills and Requirements:

· Ph.D. or MS Degree in Pharmaceutical Sciences, Chemistry and/or Chemical Engineering preferred. 12+ years of related industry experience required.

· Demonstrated in-depth technical expertise in formulation and drug substance/product process development of biologics, including process scale-up from pilot plants to large-scale facilities.

· Experience with bioconjugation and devices preferred.

· Proven experience in the generation of relevant sections of IND and BLA filing.

· 8+ years of experience in technical leadership role that includes experience managing people with demonstrated ability to build and develop a high performing team.

· Self-motivated leader with exceptional influencing, partnership, and collaboration skills to solve scientific and business problems and drive results within a matrix environment.

· Understanding of industry best practices & trends to challenge status-quo and drive change.

· Knowledge of the cGMP practices and compliance requirements.

· Excellent written, presentation, and verbal communication skills with ability to interact professionally and effectively with internal and external constituents.

If you are interested in working at Aliada, please submit your resume noting your specific position interest to: careers@aliadatx.com.

Applicants must be authorized to work for ANY employer in the U.S. We are unable to sponsor or take over sponsorship of employment Visa at this time.

Employment agencies are an important component of our talent acquisition strategy, and we value the partnerships we have built with our preferred vendors. We will not accept unsolicited resumes from employment agencies for any employment opportunity.
All resumes submitted by search firms to any employee at Aliada or directly to hiring managers in any form without a signed agreement between the parties will be deemed unsolicited in nature, and no fee will be paid in the event the candidate is hired as a result of the referral or through other means.

Aliada is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity, national origin, veteran status, or genetic information. Aliada is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities.